In 1602 Capt. Bartholomew Gosnold was the first of the Old World explorers to view the area now known as Hyannis. Settlers from England incorporated the Town of Barnstable in 1639.

In 1666 Nicholas Davis, first settler and businessman, built his warehouse for pickling oysters in brine, on Lewis Bay at the foot of what is now Pleasant Street.

In 1690 Edward Coleman, Jr. built the first permanent residence at the head of Lewis Bay. John Thatcher provided the first mail trip to Boston. Salary: one dollar per day. The early settlers of the Town of Barnstable were primarily farmers who turned toward the sea. The maritime harvest was plentiful, for frequently there were drift whales on our beaches. By the close of the 19th century, over 800 shipmasters sailed worldwide from the homeport of Barnstable, Massachusetts. Many of these brave mariners established strong family ties in our area, and their descendents are still vital, well-known members of our community today.

From the days of the earliest settlements the Indian Sachem Yanno or Iyanno, for whom Hyannis is named, sold the area presently known as Hyannis as far as Craigville for 20 pounds and two small pairs of pants. Until the advent of railroads and steamships, life on the seas greatly determined the growth of the Town of Barnstable. By 1830, Hyannis center contained one house of worship, the Baptist Church on Bearse's Way (now known as Main Street), four schoolhouses, two or three stores and a tavern.